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US 4,230,617 AGranted
Somatostatin analogues
AssigneeAmerican Home Products Corporation
InventorDimitrios Sarantakis
Life of this patent
Estimating the term…
Abstract
The polypeptides, ##STR1## the linear precursor intermediates therefor or non-toxic acid addition salts thereof in which X.sub.2 is NH.sub.2, Ala-Gly-, Ala-D-Ala-, Gly-Gly-Gly-, lower alkanoyl or benzoyl; X.sub.4 is Arg, His, D-Arg or D-His; X.sub.5 is His, Tyr, Glu, D-His, D-Tyr or D-Glu; X.sub.7 is Trp, Tyr, Met or His; and X.sub.8 is Trp or D-Trp; inhibit the release of growth hormone and are useful in the treatment of acromegaly and diabetes.
Claims4
A compound of the formula:
- ##STR3## its linear precursor intermediates or non-toxic acid addition salts thereof in which
- X.sub.2 is NH.sub.2, Ala-Gly-, Ala-D-Ala, Gly-Gly-Gly-, lower alkanoyl or benzoyl;
- X.sub.4 is Arg, His, D-Arg, or D-His;
- X.sub.5 is His, Tyr, Glu, D-His, D-Tyr, or D-Glu;
- X.sub.7 is Trp, Tyr, Met, or His;
- and
- X.sub.8 is Trp or D-Trp.
4 more elements
Dependencies are inferred from the claim text.