Preparation of a caryophyllene alcohol mixture
AssigneeInternational Flavors & Fragrances Inc.
InventorsCynthia J. Mussinan, Braja D. Mookherjee, Manfred H. Vock, Joaquin F. Vinals, Jacob Kiwala, Frederick L. Schmitt
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Abstract
A process for preparing a mixture of isomers of caryophyllene alcohol and dihydrocaryophyllene alcohol including 10,10-dimethyl-2,6-dimethylene bicyclo[7.2.0]undecan-5-ol by isomerizing caryophyllene oxide or dihydrocaryophyllene oxide using an aluminum isopropylate catalyst in a toluene solvent at temperatures in the range of from about 100.degree. C. up to about 150.degree. C. is described.
Claims5
The process for rearranging a caryophyllene derivative selected from the group consisting of caryophyllene oxide and dihydro caryophyllene oxide using an aluminum isopropylate catalyst and a toluene solvent comprising the steps of (i) intimately admixing aluminum isopropylate, toluene and the caryophyllene derivative to form a mixture;
- (ii) heating the resulting mixture at a temperature of from 100.degree. C. up to 150.degree. C. for a period of time of from about 1 up to about 5 hours;
- and (iii) recovering the rearranged caryophyllene oxide or dihydro caryophyllene oxide, a mixture of alcohols, from the reaction mass;
- the concentration of aluminum isopropylate catalyst in the reaction mass varying from about 0.025 molar up to about 0.75 molar;
- and the concentration of caryophyllene oxide or dihydro caryophyllene oxide in the reaction mass varying from about 0.25 molar up to about 1.00 molar.
Dependencies are inferred from the claim text.