Back to results
US 4,229,584 AGranted
Ureylenebis(anionic substituted phenylene carbonyl)imino naphthalene sulfonic acids and naphthalene carboxylic acids and their salts
AssigneeAmerican Cyanamid Company
InventorsRansom B. Conrow, Seymour Bernstein
Life of this patent
Estimating the term…
Abstract
Ureylenebis(anionic substituted phenylene carbonyl)imino naphthalene sulfonic acids and naphthalene carboxylic acids and their salts, which are useful as inhibitors of the complement system of warm-blooded animals. Naphthyl sulfobenzamido salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
Claims29
A compound of the formula:
- ##STR5## wherein R is selected from the group consisting of SO.sub.3 X and COOY, wherein X is selected from the group consisting of hydrogen and alkali metal and Y is selected from the group consisting of hydrogen, alkali metal and C.sub.1 -C.sub.6 alkyl;
- R.sub.1, R.sub.4, R.sub.5 and R.sub.6 are selected from the group consisting of hydrogen and SO.sub.3 X, wherein X is as previously defined;
- R.sub.2 is selected from the group consisting of hydrogen and acetamido;
- with the proviso that there is no R.sub.1 or R.sub.2 substituent when the bridgehead carbonylimino is attached at the carbon 2-position of the respective ring;
- with the further proviso that each naphthalene moiety must contain two or three SO.sub.3 X substituents, wherein X is as previously defined;
- R.sub.3 is selected from the group consisting of hydrogen;
- SO.sub.3 X and COOY, wherein X and Y are as previously defined;
- and R.sub.7 is selected from the group consisting of hydrogen, hydroxy and SO.sub.3 X is as previously defined.
5 more elements
Dependencies are inferred from the claim text.