Process for the preparation of sterically uniform, natural 6-thiatetracycline derivatives
AssigneeMerck Patent GmbH
InventorRichard Kirchlechner
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Abstract
A process for the preparation of racemic 6-thiatetracycline derivatives comprises treating a mixture of epimers of corresponding 1,4,4a,5,5a,6,11,12a-octahydro-3,12-dihydroxy-1,11-dioxo-6-thianaphthacene -2-carboxamides with a saturated heterocyclic secondary amine having a total of 4 to 12 carbon atoms for a sufficient length of time at temperatures of about 15.degree.-120.degree. C.
Claims8
A process for the preparation of racemic sterically uniform 6-thiatetracycline derivatives of "natural" configuration which comprises treating a mixture of epimers of corresponding 1,4,4a,5,5a,6,11,12a-octahydro-3,12-dihydroxy-1,11-dioxo-6-thia-naphthacen e-2-carboxamides with a saturated heterocyclic amine having a total of 4 to 12 carbon atoms and one ring N atom at a temperature of about 15.degree.-120.degree. C. for a length of time effective to produce said racemic sterically uniform derivatives of "natural" configuration.
Dependencies are inferred from the claim text.