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US 4,229,575 AGranted
7-(2,3-Dihydrobenzo-5-furanyl)-acetamido cephalosporin derivatives
AssigneeRichardson-Merrell Inc.
InventorEkkehard H. Bohme
Life of this patent
Estimating the term…
Abstract
This invention is directed to new 7-(2,3-dihydrobenzo-5-furanyl)acetamido cephalosporin derivatives and methods for preparing them.
Claims11
A compound selected from the formula ##STR12## wherein W is selected from the group consisting of H, --NHR.sub.4, --OH, --CO.sub.2 R.sub.5 and --SO.sub.3 R.sub.5, wherein R.sub.4 is hydrogen, a straight or branched 2 to 5 carbon alkanoyl group or an alkoxycarbonyl group in which the alkoxy moiety is straight or branched and has from 1 to 4 carbon atoms and R.sub.5 is hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms;
- R.sub.1 is hydrogen or methoxy, R.sub.2 is selected from the group consisting of hydrogen, an alkanoyloxy group in which the alkanoyl moiety is straight or branched and has from 2 to 5 carbon atoms and a heterocyclic thio group selected from the group consisting of 1,3,4-thiadiazol-2-ylthio, 5-methyl-1,3,4-thiadiazol-2-ylthio, 1,3,4-oxadiazol-2-ylthio, 5-methyl-1,3,4-oxadiazol-2-ylthio, tetrazol-5-ylthio, 1-methyltetrazol-5-ylthio, 1,2,3-triazol-5-ylthio and 1-methyl-1,2,3-triazol-5-ylthio;
- R.sub.3 is selected from the group consisting of hydrogen, a straight or branched alkyl group of from 1 to 4 carbon atoms, an alkanoyloxymethyl group in which the alkanoyl moiety is straight or branched and has from 2 to 5 carbon atoms, an alkanoylaminomethyl group wherein the alkanoyl moiety is straight or branched and has from 2 to 5 carbon atoms and the amino nitrogen is substituted with hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms, an alkoxycarbonylaminomethyl group wherein the alkoxy moiety is straight or branched and has from 1 to 4 carbon atoms and the amino nitrogen is substituted with hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms, a p-(alkanoyloxy)benzyl group in which the alkanoyl moiety has from 2 to 5 carbon atoms and is straight or branched, and an aminoalkanoyloxymethyl group wherein the alkanoyl moiety is straight or branched and has from 2 to 15 carbon atoms and the amino nitrogen is hydrogen, mono- or di-substituted with a straight or branched alkyl group of from 1 to 4 carbon atoms;
- and non-toxic pharmaceutically acceptable salts and individual optical isomers thereof.
Dependencies are inferred from the claim text.