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US 4,229,574 AGranted
Indole cephalosporin derivatives
AssigneeYeda Research and Development Co. Ltd.
InventorsAbraham Nudelman, Abraham Patchornik
Life of this patent
Estimating the term…
Abstract
New indole derivatives of cephalosporin compounds have been prepared which are useful as antibiotics.
Claims5
A compound selected from the formula ##STR11## wherein W is hydrogen, a --CO.sub.2 R.sub.4 group wherein R.sub.4 is hydrogen, a straight or branched 1 to 4 carbon alkyl group, a straight or branched alkanoyloxymethyl group in which the alkanoyl group has from 2 to 5 carbon atoms;
- R.sub.1 is hydrogen or methoxy;
- R.sub.2 is chloro, bromo or methoxy, R.sub.3 is hydrogen, a straight or branched alkyl group of from 1 to 4 carbon atoms, a straight or branched alkanoyloxymethyl group in which the alkanoyl moiety has from 2 to 5 carbon atoms and is straight or branched, an alkanoylaminomethyl group in which the alkanoyl moiety is straight or branched and has from 2 to 5 carbon atoms and the amine nitrogen is substituted with a straight or branched alkyl group having 1 to 4 carbon atoms or is unsubstituted;
- an alkoxycarbonylaminomethyl group in which the alkoxy moiety is straight or branched and has from 1 to 4 carbon atoms and the amine nitrogen is substituted with a straight or branched alkyl group of from 1 to 4 carbon atoms or is unsubstituted, p-(alkanoyloxy)benzyl group in which the alkanoyl moiety is straight or branched and has from 2 to 5 carbon atoms;
- an aminoalkanoyloxymethyl group in which the alkanoyl moiety has from 2 to 15 carbon atoms and the amino nitrogen is mono- or di-substituted with a straight or branched alkyl group having from 1 to 4 carbon atoms or is unsubstituted;
- or pharmaceutically acceptable salts thereof.
2 more elements
Dependencies are inferred from the claim text.