Acetylthienamycin production
AssigneeMerck & Co., Inc.
InventorsJean S. Kahan, Frederick M. Kahan, Robert T. Goegelman, Edward O. Stapley, Sebastian Hernandez
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Abstract
The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antiobiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of thienamycin.
Claims2
A process for the production of N-acetyl thienamycin which comprises cultivating Streptomyces cattleya in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic conditions and recovering the N-acetyl thienamycin so produced.
Dependencies are inferred from the claim text.