Method for controlling hypertension and compositions
AssigneeMcNeilab, Inc.
InventorChris R. Rasmussen
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Abstract
A method for controlling hypertension by administering to hypertensive subjects a N-aryl-N'-(2-imidazolidinylidene)urea compound and compositions suitable therefor are described.
Claims17
A method which comprises administering to a hypertensive animal, a therapeutically effective antihypertensive amount of a compound selected from the group consisting of (a) an N-aryl-N'-(2-imidazolidinylidene)urea having the formula:
- ##STR9## wherein Ar is phenyl substituted with from 0 to 3 substituents independently selected from the group consisting of fluoro, chloro, bromo, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, methylthio, methylsulfonyl, methylsulfinyl and cyano, and (b) a pharmaceutically acceptable salt thereof.
A method of reducing arterial pressure in hypertensive subjects which comprises administering to a hypertensive subject from about 5 to 500 milligrams per unit dose of a urea compound represented by the formula ##STR10## wherein each R is independently selected from the group consisting of chloro, bromo, methyl, ethyl and methoxy, n is an integer of from 0 to 3;
- and pharmaceutically acceptable salts thereof.
A pharmaceutical composition in dosage unit form for treating hypertension comprising a therapeutically effective antihypertensive amount of a urea compound selected from the group consisting of (a) an N-aryl-N'-(2-imidazolidinylidene)urea having the formula:
- ##STR11## wherein Ar is phenyl substituted with from 0 to 3 substituents independently selected from the group consisting of fluoro, chloro, bromo, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, methylthio, methylsulfonyl, methylsulfinyl, and cyano, and (b) a pharmaceutically acceptable salt thereof;
- wherein said urea compound is in admixture with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.