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US 4,229,455 AGranted
Imino-bridged benzocycloheptapyridines
AssigneeMerck & Co., Inc.
InventorsKenneth L. Shepard, Wasyl Halczenko
Life of this patent
Estimating the term…
Abstract
Benzocycloheptapyridines with an imine bridge in the cycloheptane ring, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease.
Claims6
A compound of structural formula:
- ##STR55## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently
- (1) hydrogen,
- (2) lower alkyl,
- (3) lower alkenyl,
- (4) phenyl-lower alkyl,
- (5) lower cycloalkyl, or
- (6) lower(cycloalkyl-alkyl),
- with the proviso that only one of R.sup.1 and R.sup.2 is other than hydrogen;
- R is
- (1) R.sup.2,
- (2) phenyl, or
- (3) di(lower alkyl)amino-lower alkyl;
- and
- R.sup.3 is
- (1) hydrogen,
- (2) halogen,
- (3) lower alkoxy,
- (4) trifluoromethylthio,
- (5) cyano, or
- (6) carboxy.
17 more elements
A pharmaceutical composition comprising a pharmaceutical carrier and an effective amount of a compound of formula:
- ##STR56## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently
- (1) hydrogen,
- (2) lower alkyl,
- (3) lower alkenyl,
- (4) phenyl-lower alkyl,
- (5) lower cycloalkyl, or
- (6) lower(cycloalkyl-alkyl),
- with the proviso that only one of R.sup.1 and R.sup.2 is other than hydrogen;
- R is
- (1) R.sup.2,
- (2) phenyl, or
- (3) di(lower alkyl)amino-lower alkyl;
- and
- R.sup.3 is
- (1) hydrogen,
- (2) halogen,
- (3) lower alkoxy,
- (4) trifluoromethylthio,
- (5) cyano, or
- (6) carboxy.
17 more elements
A method of treating anxiety comprising the administration of an effective amount of a compound of formula:
- ##STR57## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently
- (1) hydrogen,
- (2) lower alkyl,
- (3) lower alkenyl,
- (4) phenyl-lower alkyl,
- (5) lower cycloalkyl, or
- (6) lower(cycloalkyl-alkyl),
- with the proviso that only one of R.sup.1 and R.sup.2 is other than hydrogen;
- R is
- (1) R.sup.2,
- (2) phenyl, or
- (3) di(lower alkyl)amino-lower alkyl;
- and
- R.sup.3 is
- (1) hydrogen,
- (2) halogen,
- (3) lower alkoxy,
- (4) trifluoromethylthio,
- (5) cyano, or
- (6) carboxy.
17 more elements
Dependencies are inferred from the claim text.