US 4,229,450 A · Carbamates of homolysergols (8.beta.-hydrohyethylergolines) and compositions thereof

Abstract

Novel ergoline derivatives are disclosed having the general formula (I) ##STR1## wherein R.sub.1 is hydrogen, and alkyl radical (C.sub.1 to C.sub.4) either straight of branched chain, Z is hydrogen, bromine, S-R.sub.IV (in which R.sub.IV is an alkyl of from C.sub.1 to C.sub.4, R.sub.II is equal to R.sub.III and is an alkyl of from C.sub.1 to C.sub.6, or R.sub.II united with R.sub.III by-(CH.sub.2).sub.n, with n from 0 to 7, to form simple heterocyclic compounds such as pyrrolidine, piperidine, hexamethyleneimine, or united with --(CH.sub.2).sub.n --A--(CH.sub.2).sub.n, with n equal to a number from 2 to 5 to form heterocyclic compounds such as A=0 and n=2 to give morpholine, A is N-R.sub.V and N=2 for piperazine, either substituted or unsubstituted, with R.sub.V being hydrogen, an alkyl of from C.sub.1 to C.sub.4, or a phenyl radical, the x--y bridge being a ##STR2## bond. A method for the preparation of such compounds and pharmaceutical compositions thereof are also disclosed.

Claims27

Dependent claims

Novel ergoline derivatives having the general formula (I) ##STR7## wherein R.sub.1 is hydrogen, an alkyl radical (C.sub.1 to C.sub.4) either straight or branched chain.

Z is hydrogen, bromine, S-R.sub.IV (in which R.sub.IV is an alkyl of from C.sub.1 to C.sub.4,
R.sub.II is equal to R.sub.III and is an alkyl of from C.sub.1 to C.sub.6, or R.sub.II united with R.sub.III form pyrrolidine, piperidine, hexamethyleneimine, morpholine or piperazine unsubstituted or N-substituted by C.sub.1 to C.sub.4 alkyl or phenyl, the x--y bridge being a ##STR8## bond.

Dependencies are inferred from the claim text.

Carbamates of homolysergols (8.beta.-hydrohyethylergolines) and compositions thereof

Life of this patent

Carbamates of homolysergols (8.beta.-hydrohyethylergolines) and compositions thereof

Life of this patent

Abstract

Claims27