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US 4,229,438 AGranted
Nonapeptides
AssigneeTakeda Chemical Industries, Ltd.
InventorsMasahiko Fujino, Osamu Nishimura, Muneo Takaoki
Life of this patent
Estimating the term…
Abstract
Novel nonapeptides of the formula: pGlu-X-Lys-Ser-Gln-Y-Z-Ser-Asn-OH wherein X is Ala or (D)-Ala; Y and Z are the same or different and each is the residue of a D-amino acid containing 3 to 9 carbon atoms, or Gly; and at least one of X, Y and Z is the residue of D-amino acid, have immunoregulator activity and are of value as medicines.
Claims11
A nonapeptide of the formula:
- pGlu-X-Lys-Ser-Gin-Y-Z-Ser-Asn-OH
- wherein X is Ala or (D)-Ala;
- Y and Z are the same or different and each is the residue of a D-amino acid selected from the group consisting of alanine, leucine, isoleucine, phenylalanine, valine, 2-amino-n-butyric acid, serine, threonine, norleucine, methionine, norvaline and tyrosine, or Gly;
- and at least one of X, Y and Z is the residue of D-amino acid.
1 more element
A pharmaceutical composition for immuno-regulation which comprises, as an active ingredient, an effective amount of a nonapeptide of the formula:
- pGlu-X-Lys-Ser-Gln-Y-Z-Ser-Asn-OH
- wherein X is Ala or (D)-Ala;
- Y and Z are the same or different and each is the residue of a D-amino acid selected from the group consisting of alanine, leucine, isoleucine, phenylalanine, valine, 2-amino-n-butyric acid, serine, threonine, norleucine, methionine, norvaline and tyrosine, or Gly;
- and at least one of X, Y and Z is the residue of D-amino acid, and a pharmaccologically acceptable carrier, excipient or diluent therefor.
1 more element
Dependencies are inferred from the claim text.