Process for the production of 1-phenyl-3-(3-trifluoromethylphenyl)-2-propanone
AssigneeHooker Chemicals & Plastics Corporation
InventorsDavid Y. Tang, Arthur M. Foster
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Abstract
The present invention provides a novel process for the production of 1-phenyl-3-(3-trifluoromethylphenyl)-2-propanone. The process comprises the steps of: (a) condensing 3-trifluoromethylbenzaldehyde with acetophenone under basic conditions to form a substituted chalcone, (b) epoxidation of the substituted chalcone to produce the corresponding epoxide, (c) converting the epoxide to a chlorohydrin, (d) catalytic hydrogenolysis of the chlorohydrin to produce a diol and subsequently converting the diol into the corresponding alcohol, and (e) oxidizing the alcohol to produce 1-phenyl-3-(3-trifluoromethylphenyl)-2-propanone.
Claims8
A method of making 1-phenyl-3-(3-trifluoromethylphenyl)-2-propanone comprising the steps of:
- (a) condensing 3-trifluoromethylbenzaldehyde with acetophenone under basic conditions to produce a substituted chalcone,
- (b) epoxidizing said substituted chalcone to produce the corresponding epoxide,
- (c) converting the epoxide to a chlorohydrin,
- (d) hydrogenating said chlorohydrin to produce a diol and subsequently converting said diol into the corresponding alcohol, and
- (e) oxidizing said alcohol to produce 1-phenyl-3-(3-trifluoromethylphenyl)-2-propanone.
Dependencies are inferred from the claim text.