Ureylene phenylene anionic naphthalenesulfonic acids
AssigneeAmerican Cyanamid Company
InventorsGerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
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Abstract
Novel ureylenebis-[substituted-phenylenecarbonylimino-substituted-phenylenesulfo nylimino]naphthalenetrisulfonic acid alkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl imino, substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, alkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
Claims8
A compound of the formulae:
- ##STR4## wherein R and R.sub.2 are selected from the group consisting of hydrogen and methyl;
- R.sub.1 and R.sub.4 are selected from the group consisting of hydrogen and --COOB, wherein B is selected from the group consisting of hydrogen and a pharmaceutically acceptable salt cation;
- R.sub.3 is selected from the group consisting of hydrogen and --SO.sub.3 A, wherein A is a pharmaceutically acceptable salt cation;
- R.sub.5 is selected from the group consisting of hydrogen and methyl;
- with the proviso that R.sub.1, R.sub.3 and R.sub.4 may not all be hydrogen;
- with the second proviso that R.sub.2 and R.sub.5 may not both be hydrogen;
- with the third proviso that neither phenyl moiety can contain both --SO.sub.3 A and --COOB.
The compound according to claim 1, 8-[5-(4-Amino-2-sulfobenzamido)-o-toluenesulfonamido]-1,3,6-naphthalenetri sulfonic acid, tetrasodium salt.
The compound according to claim 1, 8-[5-(4-Amino-2-sulfobenzamido)-o-toluenesulfonamido]-1,3,5-naphthalenetri sulfonic acid, tetrasodium salt.
The compound according to claim 1, 8-[5-(4-Amino-2-sulfobenzamido)-2,4-xylenesulfonamido]-1,3,6-naphthalenetr isulfonic acid, tetrasodium salt.
The compound according to claim 1, 8-[5-(4-Amino-2-sulfobenzamido)-2,4-xylenesulfonamido]-1,3,5-naphthalenetr isulfonic acid, tetrasodium salt.
The compound according to claim 1, 8-[N.sup.3 -(4-Amino-2-sulfobenzoyl)metanilamido]-1,3,6-naphthalenetrisulfonic acid, tetrasodium salt.
Dependencies are inferred from the claim text.