Ureylene phenylene anionic naphthalenesulfonic acids
AssigneeAmerican Cyanamid Company
InventorsGerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
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Abstract
Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-subsituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-na phthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
Claims9
A compound of the formula:
- ##STR4## wherein R, R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen and methyl;
- and A is a pharmaceutically acceptable salt cation.
The compound according to claim 1, 8,8'-[Ureylenebis[(m-phenylenesulfonylimino) (4-methyl-3,1-phenylenesulfonyl)imino]]di-1,3,5-naphthalenetrisulfonic acid, hexasodium salt.
The compound according to claim 1, 8,8'-[Ureylenebis[(m-phenylenesulfonylimino) (4-methyl-3,1-phenylsulfonyl)imino]]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
The compound according to claim 1, 8,8'-[Ureylenebis[[(1,3-phenylenesulfonylimino)-1,3-phenylenesulfonyl]imin o]]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
The compound according to claim 1, 8,8'-[Ureylenebis[[(1,3-phenylenesulfonylimino)-1,3-phenylenesulfonyl]imin o]]di-1,3,5-naphthalenetrisulfonic acid, hexasodium salt.
The compound according to claim 1, 8,8'-[Ureylenebis[[[(6-methyl-3,1-phenylene)sulfonyl]imino]-[[(6-methyl-3, 1-phenylene)sulfonyl]imino]]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Dependencies are inferred from the claim text.