Process for heterogeneous nucleophilic substitution reactions
AssigneeChinoin Gyogyszer es Vegyeszeti Termeker Gyara Rt.
InventorsLaszlo Toke, Gabor T. Szabo, Gabor Szabo, Lajos Nagy, Istvan Rusznak
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Abstract
The invention relates to a process for nucleophilic substitution reactions. According to the invention the reaction is carried out in a heterogeneous system, consisting of a solid and a dissolved reactant, one or several organic solvents, one or several linear polyether derivatives, and/or amino compounds and water. The volume of the water is preferably at the most 100% of the volume of the organic solvent and more preferably 5%. According to the invention the anhydrous reaction medium which is difficult to ensure, is not necessary and the use of the expensive and in industrial scales unavailable crown ethers is eliminated.
Claims11
A process for carrying out a nucleophilic substitution reaction which comprises the step of conducting the reaction in a heterogeneous system containing a nucleophilic reagent selected from the group consisting of alkali metal, alkali earth metal or ammonium cyanides and carboxylates and a benzyl halide substrate wherein one of said nucleophilic reagent and said benzyl halide substrate is in a solid state and the other is in a dissolved state, a water-immiscible solvent, water, and a phase transfer agent selected from the group consisting of a polymerizate of a lower alkylene glycol, a polymerizate of a lower alkylene glycol with a dilower alkylamine group or 1-piperidyl group terminally substituted thereon, a mixture of a polymerizate of a lower alkylene glycol and a triloweralkyl amine, and mixtures thereof.
Dependencies are inferred from the claim text.