Immunosuppressive m-fluorodithiocarbanilates
AssigneeCalifornia Polytechnic State University Foundation
InventorsHewitt G. Wight, Tracey G. Call, Marvin L. Mortensen
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Abstract
The present invention to certain immunosuppressive .omega.-(alkoxycarbonyl)alkyl m-fluorodithiocarbanilates. These compounds surprisingly and unexpectedly exhibit useful immunosuppressive effects in the treatment of tissue transplantation rejection phenomena and are useful in the symptomatic treatment of autoimmune diseases.
Claims5
A compound of the formula ##STR5## wherein T is nitro, fluoro, chloro, bromo, trifluoromethyl, lower alkylsulphonyl, phenylsulphonyl, or (lower alkyl)phenylsulphonyl;
- wherein s is the integer zero or one;
- wherein C.sub.m H.sub.2m is alkylene of one to 5 carbon atoms, inclusive;
- and
- wherein R.sub.2 is alkyl of one to 12 carbon atoms, inclusive;
A compound of the formula ##STR6## wherein C.sub.m H.sub.2m is alkylene of one to 5 carbon atoms, inclusive;
- and
- wherein R.sub.2 is alkyl of one to 12 carbon atoms, inclusive;
A compound of the formula ##STR7## wherein R.sub.2 is alkyl of one to 12 carbon atoms, inclusive;
- and
A compound of the formula ##STR8## wherein R.sub.12 is alkyl of one to 2 carbon atoms, inclusive.
Dependencies are inferred from the claim text.