Thiopyrano-benzopyrans, compositions and method of use thereof
AssigneeFisons Limited
InventorsHugh Cairns, Anthony H. Ingall
Life of this patent
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Abstract
There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl, and E is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group, and pharmaceutically acceptable derivatives thereof. There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.
Claims9
A compound of formula I, ##STR8## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl, each of R.sub.1, R.sub.2, R.sub.5, R.sub.6, R.sub.7 and R.sub.8, when they contain carbon, containing up to 8 carbon atoms, and
- E is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group,
- and pharmaceutically acceptable salts, esters and amides thereof.
Dependencies are inferred from the claim text.