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US 4,228,168 AGranted
Azepino [1,2,3-lm]-.beta.-carboline compounds and pharmaceutical composition thereof
AssigneeTanabe Seiyaku Co., Ltd.
InventorsYasuhiko Sato, Tomishige Mizoguchi, Yukitsuka Kudo, Ryuichi Ishida
Life of this patent
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Abstract
An azepino[1,2,3-lm]-.beta.-carboline compound of the formula: ##STR1## wherein R.sup.1 is hydrogen, cycloalkyl of 3 to 7 carbon atoms, phenyl, hydroxy, alkoxycarbonyl of 2 or 3 carbon atoms or alkanoyl of 2 or 3 carbon atoms, and A is single bond or straight or branched alkylene of one to 5 carbon atoms. Several methods of preparing the compound [I] are disclosed. The compound [I] and a pharmaceutical acceptable acid addition salt thereof have a potent anti-anoxic activity.
Claims7
An azepino[1,2,3-lm]-.beta.-carboline compound of the formula:
- wherein R.sup.1 is hydrogen, cycloalkyl of 3 to 7 carbon atoms, phenyl, hydroxy, alkoxycarbonyl of 2 or 3 carbon atoms or alkanoyl of 2 or 3 carbon atoms, and A is single bond or straight or branched alkylene of one to 5 carbon atoms, or a pharmaceutically acceptable acid addition salt
Dependencies are inferred from the claim text.