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US 4,228,164 AGranted
Condensed purine derivatives useful for improving peripheral circulation
AssigneeChinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
InventorsRudolf Szebeni, Dezso Korbonits, Kalman Harsanyi, Molnar Leventene, Laszlo Szekeres, Gyula Papp, Gyula Sebestyen
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Abstract
A compound of the formula ##STR1## wherein R is hydroxy, alkoxy or acyloxy Q is sulfur or a .dbd.N--R.sup.1 group, wherein R.sup.1 is hydrogen, C.sub.1-5 alkyl or aralkyl or C.sub.2-4 acyl, or a pharmaceutically acceptable acid addition salt thereof.
Claims10
A compound of the formula ##STR14## wherein R is hydroxy, or acetyloxy Q is sulfur or a --N--R.sup.1 group, wherein R.sup.1 is hydrogen, C.sub.1-5 alkyl benzyl or C.sub.2-4 acyl,
- or a pharmaceutically acceptable acid addition salt thereof.
A compound selected from the group consisting of
- 1,3-dimethyl-2,4-dioxo-7-hydroxy-9-benzyl-6,7,8,9-tetrahydro-pyrimido[2,1-f ]purine;
- 1,3-dimethyl-2,4-dioxo-7-hydroxy-6,7,8,9-tetrahydro-pyrimido[2,1-f]purine;
- 1,3-dimethyl-2,4-dioxo-7-acetoxy-9-acetyl-6,7,8,9-tetrahydro-pyrimido[2,1-f ]purine;
- 1,3-dimethyl-2,4-dioxo-7-acetoxy-9-benzyl-6,7,8,9-tetrahydro-pyrimido[2,1-f ]purine;
- 1,3-dimethyl-2,4-dioxo-7-acetoxy-6,7,8,9-tetrahydro-thiazino-[2,1-f[purine;
- and
- 1,3-dimethyl-2,4-dioxo-7-hydroxy-6,7,8,9-tetrahydro-thiazino-[2,1-f]purine.
4 more elements
Dependencies are inferred from the claim text.