Polymers containing prostaglandin radicals, process for their preparation and use thereof
OwnerPaolo Ferruti, Rodolfo Paolettiinventors
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Abstract
There are disclosed non-toxic polymers having a molecular weight between 1,000 and 1,500,000 and containing prostaglandin radicals directly connected or connected through an oxyalkylenic, aminoalkylenic, or oxyaminoalkylenic chain to a polyacrylic or polymethacrylic backbone. Upon entry of the polymer into the body, the prostaglandin radicals are hydrolyzed causing free prostaglandins to be released in the body. Methods for making the non-toxic polymers and therapeutic compositions containing the non-toxic polymers are also disclosed.
Claims13
A non-toxic polymer having a molecular weight between 1,000 and 1,500,000 containing prostaglandin radicals bound to a polyacrylic or polymethacrylic backbone either directly or through oxyalkylenic, aminoalkylenic or oxyaminoalkylenic chains, said polymer containing units of the formula ##STR5## wherein R represents H or CH.sub.3, A represents an alkylene radical terminated at both ends with an --NH-- or --O-- group, n represents 0 or 1 in both occurences, B represents --OPg or --CO--Pg wherein Pg represents a prostaglandin residue, and D represents a divalent radical supplied by a comonomer selected from the group consisting of 1-acryloyl-4-methyl piperazine, N-acryloyl morpholine, N-vinyl pyrrolidone, divinylbenzene, methylene bisacrylamide, N,N'-bisacryloyl piperazine, N,N'-bisacryloyl N,N'-dimethylethylene diamine.
Dependencies are inferred from the claim text.