Method of inhibiting dextransucrase and oral compositions for use therein
AssigneeIowa State University Research Foundation, Inc.
InventorsJohn F. Robyt, John N. Zikopoulos
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Abstract
Dextransucrase synthesis of dextran from sucrose is inhibited by novel fluorosucroses which are substituted with fluorine for at least the C.sub.6 hydroxyl, and which may also be substituted with fluorine for other hydroxyls. Oral compositions containing such fluorosucrose can be used to control dextran formation in the mouth. Dextran comprises the principal component of dental plaque.
Claims26
The method of inhibiting dextransucrase synthesis of dextran from sucrose, comprising introducing into an aqueous substrate containing sucrose and dextransucrase an inhibitory amount of at least one fluorosucrose which has been substituted at least at the 6-position with a fluorine atom for the hydroxyl group.
An oral composition comprising a carrier suitable for use in the oral cavity containing an amount of at least one fluorosucrose effective for inhibiting the dextransucrase synthesis of dextran, said fluorosucrose having fluorine substituted for at least the C.sub.6 hydroxyl.
A toothpaste containing from 1 to 5 weight percent of C.sub.6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
A mouthwash containing from 20 to 30 grams per liter of C.sub.6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Water soluble tablets suitable for use in the mouth, containing from 1 to 5 weight percent per table of C.sub.6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
Chewing gum in stick form containing from 1 to 5 weight percent of C.sub.6 -substituted fluorosucrose selected from the class consisting of 6-fluorosucrose, 6,1'-difluorosucrose, 6,6'-difluorosucrose, and 6,1',6'-trifluorosucrose, and mixtures thereof.
6-fluorosucrose.
6,1'-difluorosucrose.
6,6'-difluorosucrose.
6,1',6'-trifluorosucrose.
Dependencies are inferred from the claim text.