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US 4,228,104 AGranted
2-Decarboxy-2-hydroxymethyl-19-hydroxy-PG.sub.1 analogs
AssigneeThe Upjohn Company
InventorJohn C. Sih
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Abstract
Prostaglandin derivatives having a 19,20-didehydro, a 19-hydroxy, or a 19-keto feature are disclosed, including processes for preparing them and the appropriate intermediates. A typical 19-hydroxy compound of this invention is 19-hydroxy-19-methyl-PGF.sub.2.alpha., methyl ester, represented by the formula ##STR1##
Claims54
A compound of the formula
- wherein R.sub.2 is hydrogen, hydroxyl, or hydroxymethyl;
- wherein R.sub.3 and R.sub.4 are hydrogen, alkyl of one to 4 carbon atoms, inclusive, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
- wherein g is zero, one, two, or three;
- wherein Q is ##STR70## wherein R.sub.5 is hydrogen or methyl, wherein W is ##STR71## and wherein X is cis- or trans-CH.dbd.CH-- or -C.tbd.C--;
- with the proviso that W is ##STR72## only when R.sub.2 is not hydroxy.
2 more elements
Dependencies are inferred from the claim text.