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US 4,228,077 AGranted
N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes
AssigneeE. R. Squibb & Sons, Inc.
InventorsMiguel A. Ondetti, Frank L. Weisenborn
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Abstract
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors. The compounds claimed in this application are those wherein B is indolyl-lower alkylene.
Claims6
A compound of the formula ##STR19## and physiologically acceptable basic salts thereof, wherein R.sub.1 is hydroxy or lower alkoxy;
- R.sub.2 is hydrogen, lower alkyl or lower alkanoyl;
- R.sub.3 is hydrogen or lower alkyl;
- R.sub.4 is hydrogen, lower alkanoyl, or benzoyl
- A is hydrogen, lower alkyl or hydroxy-lower alkylene;
- B is ##STR20## X is oxygen or sulfur;
- m is zero, 1, 2, 3 or 4;
- and
- n is zero or 1.
5 more elements
Dependencies are inferred from the claim text.