US 4,228,008 AGranted

Chromatographic device for simultaneous collection and evaporation of sequential volatile non-aqueous eluates

AssigneeHoffmann-La Roche Inc.

InventorsRobert J. Karol, Raymond E. Grew

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Abstract

The present disclosure relates to a chromatographic device for the simultaneous collection and evaporation of sequential volatile non-aqueous eluates. The device integrates collection and evaporation steps by continuously feeding the collected eluate directly to an evaporation vessel via a column delivery tube. As the solvent is evaporated from the evaporation vessel, eluate is continuously fed to said vessel, thereby eliminating the need for manual transfer and reducing the chances of contamination. The device increases the surface area available for evaporation, allows for the evaporation of volumes of solvent greater than the capacity of the evaporation vessel and allows for as much as a 5-fold reduction in the time necessary to carry out the chromatography and evaporation procedure.

Claims5

Dependent claims

A chromatographic device for the simultaneous collection and evaporation of sequential volatile organic eluates which comprises:

a. a column for receiving sample to be separated,
b. a means for retaining said column,
c. a separating matrix disposed within said column,
d. a column delivery tube at the lower end of said column,
e. a receptacle for receiving eluate, said vessel affixed in such a position to allow for communication of said vessel with the terminal end of said column delivery tube,
f. a container for receiving eluate, said container having inlet means at several points and being positioned to allow for communication of said inlet means with the terminal end of said column delivery tube,
g. an evaporating gas source, said source positioned to allow communication within said receptacle for receiving eluate,
h. a means for maintaining a constant temperature in which is placed said receptacle for receiving eluate,
i. a means for controlling the rate of flow of said eluate,
j. a means for housing said device.

7 more elements

Dependencies are inferred from the claim text.