Process for manufacturing .alpha.-chloroarylacetic acids
AssigneeHoechst France
InventorsEmmanuel Herman, Helmut Diery, Michel Soreau, Yani Christidis
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Abstract
Glyoxylic acid and hydrochloric acid are reacted with an aromatic compound having at least one substituent group selected from among the alkyl, aryl, hydroxy, alkoxy and aryloxy groups. The glyoxylic acid is used in a concentration comprised between 60 and 100% and the hydrochloric acid is used in as concentrated an aqueous solution as possible, e.g. in an organic solvent medium such as acetic acid. An acid catalyst such as zinc chloride may be used. The reaction may be carried out under pressure. The products are useful in various syntheses e.g. to produce amino acids or arylacetic acids with medicinal uses.
Claims19
Process for producing alphachloroarylacetic acids comprising mixing glyoxylic acid and hydrochloric acid and then reacting with an aromatic compound comprising a benzene ring and having thereon at least one substituent group selected from the group consisting of alkyl, aryl, hydroxy, alkoxy and aryloxy, and having at least one free position capable of fixing a --CHCl--COOH group.
A process for producing alpha-chloroarylacetic acids comprising reacting glyoxylic acid and hydrochloric acid with an aromatic compound having at least one free position capable of fixing a --CHCl--COOH group, said aromatic compound being selected from the group consisting of toluene, xylenes, mesitylene, pseudocumene, di-tertiobutyl-2,6-phenol, methoxy-4 toluene, biphenyl oxide and biphenyl.
Dependencies are inferred from the claim text.