Substituted phenylvinyl cyclopropyl ketones
AssigneeSterling Drug Inc.
InventorJoseph C. Collins
Life of this patent
Estimating the term…
Abstract
Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester. The intermediate iodides are prepared by condensing a methyl cyclopropyl ketone with an aromatic aldehyde to give an arylvinyl cyclopropyl ketone, reducing the latter to an arylethyl cyclopropyl carbinol or arylvinyl cyclopropyl carbinol, treating the carbinol with phosphorus tribromide and then with zinc bromide to give an arylalkyl or arylalkenyl bromide, and then replacing the bromine atom by iodine.
Claims7
A compound of the formula ##STR13## wherein R is hydrogen or lower-alkyl of 1 to 4 carbon atoms, and Ar is phenyl substituted by a member selected from the group consisting of carboxy, carbo-lower-alkoxy of 2 to 4 carbon atoms, alkanoylamino of 1 to 4 carbon atoms, dialkylamino where alkyl has from 1 to 4 carbon atoms, and aminosulfonyl.
Dependencies are inferred from the claim text.