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US 4,227,006 AGranted
N.sup.2 -Dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
AssigneeMitsubishi Chemical Industries Limited
InventorsShosuke Okamoto, Ryoji Kikumoto, Yoshikuni Tamao, Shinji Tonomura, Kazuo Ohkubo
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Abstract
N.sup.2 -dansyl-L-arginine esters and amides or the acid addition salts thereof with a pharmaceutically acceptable acid have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
Claims4
N.sup.2 -dansyl-L-argininamides of the formula ##STR74## wherein R.sub.2 =H
- R.sub.1 =--CH.sub.2 --CH.sub.2 --CO.sub.2 --CH.sub.3.
N.sup.2 -dansyl-L-argininamides of the formula ##STR75## wherein R.sub.2 =H
- R.sub.1 =--CH.sub.2 --CH.sub.2 --CO.sub.2 --C.sub.2 H.sub.5.
N.sup.2 -dansyl-L-argininamides of the formula ##STR76## wherein R.sub.2 =CH.sub.3
- R.sub.1 =--CH.sub.2 --CH.sub.2 --CO.sub.2 --CH.sub.3.
N.sup.2 -dansyl-L-argininamides of the formula ##STR77## wherein R.sub.2 =CH.sub.3
- R.sub.1 =--CH.sub.2 --CH.sub.2 --CO.sub.2 C.sub.2 H.sub.5.
Dependencies are inferred from the claim text.