8-Chloro-5,6,7,8-tetrahydro-2-quinolone and 8-bromo-5,6,7,8-tetrahydro-2-quinolone, the hydrochloride or hydrobromide thereof and process for their manufacture
AssigneeHoechst Aktiengesellschaft
InventorsHelmut Meidert, Werner H. Muller, Wilfried Pressler
Life of this patent
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Abstract
8-Chloro-5,6,7,8-tetrahydro-2-quinolone and 8-bromo-5,6,7,8-tetrahydro-2-quinolone, the hydrochloride or hydrobromide thereof and their manufacture by reacting 3,4,5,6,7,8-hexahydro-2-quinolone with chlorine or bromine in an inert solvent at 10.degree. to 50.degree. C. with heating of the reaction mixture to 60.degree. to 80.degree. C. after the halogen addition.
Claims12
8-halo-5,6,7,8-tetrahydro-2-quinolone of the formula ##STR4## in which X is chlorine or bromine, and the hydrohalide thereof.
8-Chloro-5,6,7,8-tetrahydro-2-quinolone of the formula ##STR5## and its hydrochloride.
8-Bromo-5,6,7,8-tetrahydro-2-quinolone of the formula ##STR6## and its hydrobromide.
Process for the manufacture of 8-chloro-5,6,7,8-tetrahydro-2-quinolone hydrochloride or 8-bromo-5,6,7,8-tetrahydro-2-quinolone hydrobromide, which comprises reacting 3,4,5,6,7,8-hexahydro-2-quinolone with chlorine or bromine in an inert solvent and at a temperature of from 10.degree. to 50.degree. C. and heating the reaction solution to 60.degree. to 80.degree. C. after termination of the halogen addition.
Process for the manufacture of 8-chloro-5,6,7,8-tetrahydro-2-quinolone or of 8-bromo-5,6,7,8-tetrahydro-2-quinolone, which comprises heating the hydrochloride of the former compound or the hydrobromide of the latter compound in an inert solvent and cooling the solution after escape of the respective hydrogen halide.
Dependencies are inferred from the claim text.