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US 4,226,988 AGranted
N-substituted paramenthane carboxamides
AssigneeWilkinson Sword Limited
InventorsHugh R. Watson, David G. Rowsell, David J. Spring
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Abstract
Novel compounds are disclosed having a physiological cooling action on the skin. The compounds are N-substituted p-methane 3-carboxamides.
Claims1
Substantially odorless, non-volatile physiologically active cooling compounds of the formula ##STR3## where R' and R", when taken together jointly represent a straight or branched chain alkylene group having a total of up to 10 carbon atoms, said alkylene group providing a chain of 4 or 5 carbon atoms the opposite ends of which are attached to the nitrogen atom to form a 5 or 6 membered heterocycle;
- a --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- group, or a CH.sub.2 CH.sub.2 NHCH.sub.2 CH.sub.2 group;
- or, when taken separately, R' represents hydrogen and R" represents a pyridyl group.
Dependencies are inferred from the claim text.