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US 4,226,980 AGranted
Novel derivatives of fortimicin B and process for preparing same
AssigneeAbbott Laboratories
InventorsMoriyuki Sato, Kenichi Mochida, Shigeo Yoshiie, Yasuki Mori
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Abstract
Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin B.
Claims5
4,2'-di-N-substituted derivatives of fortimicin B, represented by the formula:
- ##STR27## wherein R.sub.1 represents a ##STR28## or -CH.sub.2 -R.sub.3 group, and R.sub.2 represents a ##STR29## or --CH.sub.2 --R.sub.4 group and wherein R.sub.4 represents an aminoalkyl group having 1 to 8 carbon atoms, hydroxyalkyl group having 1 to 8 carbon atoms, carbamoylaminoalkyl group having 2 to 9 carbon atoms or .omega.-aminohydroxyalkyl group having 2 to 9 carbon atoms wherein the amino group and hydroxy group are bonded to different carbon atoms, and R.sub.3 represents a carbamoylaminoalkyl group having 2 to 9 carbon atoms, and the pharmaceutically acceptable non-toxic acid addition salts thereof.
Dependencies are inferred from the claim text.