Guanylhydrazones and medicaments containing them
AssigneeChoay S.A.
InventorsHenri Orzalesi, Jean Castel
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Abstract
New guanylhydrazones of phenoxyacetic acid. These guanylhydrazones, also their physiologically acceptable salts, are characterized by the following general formula I in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R and R' have the meanings which are hereinafter described. ##STR1## The new guanylhydrazones are useful as medicaments, in particular antimitotic, IMAO and platelet antiagregant activity.
Claims33
A guanyl hydrazone of the following general formula (I):
- ##STR3## wherein:
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be identical or different, represent hydrogen, halogen, lower alkyl or alkoxy of which the alkyl is lower alkyl;
- and
- R and R', which may be identical or different, represent hydrogen or methyl, and the physiologically acceptable salts thereof.
A pharmaceutical composition having therapeutic properties which comprises a therapeutically acceptable carrier and in a therapeutically effective amount, to inhibit platelet aggregation a guanyl hydrazone of the following general formula (I):
- ##STR4## wherein:
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be identical or different, represent hydrogen, halogen, lower alkyl or alkoxy wherein the alkyl is lower alkyl;
- and
- R and R', which may be identical or different, represent hydrogen or methyl,
- and the physiologically acceptable salts thereof.
Dependencies are inferred from the claim text.