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AssigneeChinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
InventorLaszlo Feuer
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A deproteinized, defatted aqueous extract of the parathyroid gland insoluble in benzene, chloroform and carbon tetrachloride is found to be L-gamma-glutamyl-taurine which has vitamin-A type activity and is generally effective for the treatment of a wide range of mammalian disorders which are directly or indirectly connected with pathological alterations of the aerobiospherical genetical adaptational system (AGAS).
L-gamma-glutamyl-taurine.
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Containing organic compounds: proteins; Peptides; Derivatives or degradation products thereof
Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof:…
Carboxylic acids, e.g. valproic acid: having an amino group
Preparations for care of the teeth, of the oral cavity or of
Term ended 7 Oct 1997 (estimated)
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My present invention relates to a hormonal substance derived from the parathyroid gland and to a method of treatment using same. The hormonal substance, LITORALON, which has been found to be L-gamma-glutamyl-taurine, has a wide range of therapeutic applications in the treatment of disorders related to pathological alterations of the aerobiospherical genetical adaptational system of mammalia.
The literature has described hormones of the parathyroid gland, namely, parathormone having a molecular weight of 8,500, which increases the blood calcium level of the organism.
This hormone is a substance of polypeptide structure and is prepared by extracting ground and degreased parathyroid gland with warm hydrochloric acid or phenol.
EXAMPLE I
10 g of lyophilized and ground parathyroid gland powder derived from cadavers or such slaughterhouse animals as cows, pigs, horses, sheep are degreased in a known manner (Aurbach) as follows:
The gland powder is mixed at room temperature with 25 ml of abs. acetone and then filtered on a glass filter No. G.sub.4. The well drained gland powder is again mixed at room temperature with 25 ml of chloroform and filtered on a glass filter No. G.sub.4 ; this operation is repeated. The filtered substance is suspended again in 25 ml of abs. acetone, and sucked on a glass filter No. G.sub.4. The obtained gland powder is dried in vacuo at room temperature. The weight of the dry substance obtained varies from 7-9 g, depending on the fat content of the initial substance.