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AssigneesKyowa Hakko Kogyo Co., Ltd., The Kitasato Institute
InventorsSatoshi Omura, Chiaki Kitao, Akira Nakagawa, Haruo Tanaka, Juichi Awaya, Ruiko Oiwa
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The present invention relates to a new composition designated as AM-1042 or asukamycin. AM-1042 has an antibiotic activity upon Gram-positive bacteria and Eimeria, and its acute toxicity (LD.sub.50 ' ip.) in mice was 48.5 mg./kg. AM-1042 has an excellent therapeutical effect on various infectious diseases caused by a parasite of Gram-positive bacteria and Eimeria. AM-1042 has been confirmed to be distinguishable from known antibiotics such as e.g. amicetin B, azomycin and manumycin. AM-1042 is produced by fermentation of a microorganism belonging to the genus Streptomyces and capable of producing AM-1042. A composition capable of preventing and curing coccidiosis of poultry containing AM-1042 as active ingredient.
A composition AM-1042 having antibiotic activity and represented by the formula:
A process for producing ##STR3## which comprises aerobically culturating a microorganism Streptomyces nodosus subsp. asukaensis in a medium until a sufficient amount of said compound is imparted to said medium, and recovering said compound therefrom.
A veterinary composition comprising as active ingredient an effective amount for preventing or treating coccidiosis of the compound ##STR4## in association with a physiologically acceptable carrier or excipient.
A method for preventing or treating coccidiosis in an animal subject which comprises administering to said animal subject an effective amount of the compound ##STR5## for preventing or treating coccidiosis as active ingredient in association with a physiologically acceptable carrier or excipient.
Dependencies are inferred from the claim text.