Pyrazoles active in the central nervous system
AssigneeAbbott Laboratories
InventorDavid L. Arendsen
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Abstract
Disclosed are pyrazoles of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, or phenyl, R.sub.2 is hydrogen or lower alkyl, R.sub.3 is alkoxy or hydroxy, R.sub.4 is lower alkyl, and the pharmaceutically acceptable acid addition salts thereof. The compounds are useful primarily as antipsychotic agents. As an example, they exhibit central nervous system activity as antischizophrenic agents.
Claims9
A compound of the formula ##STR5## wherein R.sub.1 is hydrogen, lower alkyl, or phenyl, R.sub.2 is hydrogen or lower alkyl, R.sub.3 is lower alkoxy or hydroxy, and R.sub.4 is lower alkyl, provided the compound wherein R.sub.2 is isopropyl when R.sub.1 is methyl, R.sub.3 is methoxy and R.sub.4 is ethyl is excluded, and the pharmaceutically acceptable acid addition salts thereof.
A method of treating schizophrenia in mammals which method comprises administering to a mammal in need of such treatment an effective amount of a compound of the formula ##STR6## wherein R.sub.1 is hydrogen, lower alkyl, or phenyl, R.sub.2 is hydrogen or lower alkyl, R.sub.3 is lower alkoxy or hydroxy, and R.sub.4 is lower alkyl, provided the compound wherein R.sub.2 is isopropyl when R.sub.1 is methyl, R.sub.3 is methoxy and R.sub.4 is ethyl is excluded, or a pharmaceutically acceptable acid addition salt thereof.
A composition for the treatment of schizophrenia, said composition comprising an effective amount of a compound of the formula ##STR7## wherein R.sub.1 is hydrogen, lower alkyl, or phenyl, R.sub.3 is lower alkoxy or hydroxy, and R.sub.4 is lower alkyl, provided the compound wherein R.sub.2 is isopropyl when R.sub.1 is methyl, R.sub.3 is methoxy and R.sub.4 is ethyl is excluded, or a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.