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US 4,226,867 AGranted
3,3-Substituted spiro-1,2,4-benzothiadiazines
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
Life of this patent
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Abstract
3,3-Substituted spiro-1,2,4-benzothiadiazines and their use in treating hypertension are disclosed.
Claims21
A compound of the formula ##STR17## wherein X.sup.1 is H or halo or trifluoromethyl,
- X.sup.2 is H, halo or --SO.sub.2 NH.sub.2,
- R is H or lower alkyl,
- R.sup.1 is H or lower alkyl,
- R.sup.2 is lower alkyl or C.sub.3 -C.sub.6 cycloalkyl
- R.sup.1 and R.sup.2 may be joined to form --(CH.sub.2)--.sub.4 or --(CH.sub.2).sub.5 --,
- R.sup.3 is H, lower alkyl, phenyl or chlorophenyl,
- m is 0 or 1 and
- n is 0 to 5
- and pharmaceutically acceptable salts thereof.
6 more elements
Dependencies are inferred from the claim text.