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US 4,226,808 AGranted
1-Aryl-2-dihalogenodeuterioalkanoylamido-1,3-propanediol antibacterial agents
AssigneeSchering Corporation
InventorTattanahalli L. Nagabhushan
Life of this patent
Estimating the term…
Abstract
Described are D-(threo)-1-p-substituted phenyl-2-dihalogeno-.alpha.-deuterioalkanoylamido-1,3-propanediols and their use as antibacterial agents.
Claims10
A D-(threo)-1-aryl-2-acylamido-1,3-propanediol of the following formula:
- ##STR6## wherein R is a member selected from the group consisting of dihalogenodeuteriomethyl and 1,2-dihalogeno-1-deuterioethyl;
- X is a member selected from the group consisting of NO.sub.2, SO.sub.2 R.sub.1, SOR.sub.1, SR.sub.1, SONH.sub.2, SO.sub.2 NH.sub.2, SONHR.sub.1, SO.sub.2 NHR.sub.1, COR.sub.1, CN, halogen, hydrogen, phenyl, and phenyl substituted by halogen, NO.sub.2 or SO.sub.2 CH.sub.3, wherein
- R.sub.1 is a member selected from the group consisting of methyl, ethyl, n-propyl and isopropyl;
- and
- Z is a member selected from the group consisting of hydrogen, an acyl radical of a hydrocarboncarboxylic acid having up to 16 carbon atoms, an acyl radical of a hydrocarbondicarboxylic acid having up to 16 carbon atoms, and an acyl radical of an aminohydrocarboncarboxylic acid having up to 12 carbon atoms;
- and the pharmaceutically acceptable salts of said acyl radicals.
3 more elements
Dependencies are inferred from the claim text.