Process for production of optically active bases
AssigneeDeutsche Gold- und Silber-Scheideanstalt vormals Roessler
InventorsKarl H. Klingler, Horst Traube
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Abstract
Optically active bases are prepared by reacting the racemic base with an optically active half amide of an unsaturated aliphatic dicarboxylic acid of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are the same of different and are hydrogen, halogen, a hydroxy group, a methyl group or a methoxy group or two of R.sub.1, R.sub.2 and R.sub.3 together are a methylenedioxy group, R.sub.4 is hydrogen or a methyl group, R.sub.5, R.sub.6 and R.sub.7 independently are hydrogen or a C.sub.1 -C.sub.4 alkyl group and n is 0 or 1 and optionally splitting an optically homogeneous salt fraction into the corresponding optically active base and the added half amide.
Claims27
A process for preparing an optically active base from a racemic base ##STR7## comprising reacting the racemic base in a solvent with an optically active half amide of an unsaturated aliphatic dicarboxylic acid of the formula ##STR8## where R.sub.1, R.sub.2 and R.sub.3 are hydrogen, halogen, a hydroxy group, a methyl group or a methoxy group or two of R.sub.1, R.sub.2 and R.sub.3 together are a methylenedioxy group, R.sub.4 is a methyl group, R.sub.5, R.sub.6 and R.sub.7 are hydrogen or a C.sub.1 -C.sub.4 alkyl group, R.sub.8 is hydrogen or a hydroxy group and n is 0 or 1.
Dependencies are inferred from the claim text.