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US 4,226,789 AGranted
Removal of nitrosamines from denitroanilines by treatment with HCl
AssigneeEli Lilly and Company
InventorsRichard F. Eizember, Kathleen R. Vogler, William N. Cannon
Life of this patent
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Abstract
The present invention is directed to a process for the removal of nitrosamines from dinitroanilines.
Claims78
The process which comprises
- (1) contacting a nitrosamine-containing dinitroaniline selected from the group consisting of
- trifluralin
- isopropalin,
- benefin,
- ethalfluralin,
- butralin,
- pendimethalin,
- fluchloralin,
- profluralin,
- dinitramine,
- 4-trifluoromethyl-2,6-dinitro-3-chloro-N,N-diethylaniline,
- 4-methyl-2,6-dinitro-N,N-bis(2-chloroethyl)aniline,
- oryzalin, and
- nitralin,
- (a) in liquid phase
- (b) with a reagent selected from the group consisting of 20-38% hydrochloric acid and gaseous HCl until the concentration of the nitrosamine has been reduced from about several thousand ppm or less;
- and
- (2) thereafter recovering the dinitroaniline.
15 more elements
The process which comprises
- (1) contacting a nitrosamine-containing dinitroaniline selected from the group consisting of
- trifluralin,
- isopropalin,
- benefin,
- ethalfluralin,
- butralin,
- pendimethalin,
- fluchloralin,
- profluralin,
- dinitramine,
- 4-trifluoromethyl-2,6-dinitro-3-chloro-N,N-diethylaniline,
- 4-methyl-2,6-dinitro-N,N-bis(2-chloroethyl)aniline,
- oryzalin, and
- nitralin,
- (a) in liquid phase
- (b) with a reagent selected from the group consisting of 20-38% hydrochloric acid and gaseous HCl until the concentration of the nitrosamine has been reduced from about 480 ppm or less;
- and
- (2) thereafter recovering the dinitroaniline.
15 more elements
The process of claim 34 in which the reagent is 33-38% hydrochloric acid.
The process which comprises
- (1) contacting a nitrosamine-containing dinitroaniline selected from the group consisting of
- trifluralin,
- isopropalin,
- benefin,
- ethalfluralin,
- butralin,
- pendimethalin,
- fluchloralin,
- profluralin,
- dinitramine,
- 4-trifluoromethyl-2,6-dinitro-3-chloro-N,N-diethylaniline,
- 4-methyl-2,6-dinitro-N,N-bis(2-chloroethyl)aniline,
- oryzalin, and
- nitralin,
- (a) in liquid phase
- (b) with a reagent selected from the group consisting of 20-38% hydrochloric acid and gaseous HCl until the concentration of the nitrosamine has been reduced from about 480 ppm or less to about 1 ppm or less;
- and
- (2) thereafter recovering the dinitroaniline.
15 more elements
Dependencies are inferred from the claim text.