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US 4,226,774 AGranted
Carbazole melonates
AssigneeHoffmann-La Roche Inc.
InventorsHarvey Gurien, Sidney Teitel
Life of this patent
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Abstract
A process for the preparation of .alpha.-methyl-carbazole-2-acetic acids, which comprises reacting an .alpha.-methyl-3-oxocyclohexane malonic acid di-lower alkyl ester with a substituted phenylhydrazine, and thereafter sequentially oxidizing and hydrolyzing the reaction product to obtain the desired acid, is described.
Claims2
A compound of the formula ##STR10## wherein R.sub.1 is lower alkyl, R.sub.2 is hydrogen, halogen, trifluoromethyl, hydroxy, lower alkyl, hydroxy-lower alkyl, lower alkylthio, amino, mono-lower alkylamino, or di-lower alkylamino;
- and R.sub.3 is halogen, trifluoromethyl, lower alkyl, hydroxy-lower alkyl, lower alkoxy, lower alkylthio, hydroxy, amino, mono-lower alkylamino or di-lower alkylamino, or R.sub.2, taken together with an adjacent R.sub.3, is also lower alkylenedioxy.
Dependencies are inferred from the claim text.