Pyrazolyl amino imidazolines as diuretic agents
AssigneeAbbott Laboratories
InventorJohn J. Kyncl
Life of this patent
Estimating the term…
Abstract
Described is a method of increasing urinary excretion by administering effective amounts to a subject in need thereof of compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, loweralkyl, lowercycloalkyl, aralkyl, aryl, pyridyl, isoquinolyl or phthalazinyl, or aryl substituted by one or more hydrogen, halo, loweralkyl, lowercycloalkyl, haloloweralkyl, aminosulfonyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, cycloalkoxy carbonyl, aminocarbonyl, diloweralkylaminocarbonyl or ##STR2## wherein n is 4 or 5. R.sub.3 is hydrogen, halogen, loweralkyl or aryl, and R.sub.4 is hydrogen, acyl, amino or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof.
Claims9
A method of increasing urinary excretion in a subject in need thereof which comprises administering to said subject an effective amount sufficient to produce increased urinary excretion of a compound represented by the structural formula ##STR8## wherein R.sub.1 and R.sub.2 are hydrogen, loweralkyl, lowercycloalkyl, benzyl, phenyl or naphthyl, pyridyl, isoquinolyl or phthalazinyl, or phenyl or naphthyl substituted by one or more hydrogen, halo, loweralkyl, lowercycloalkyl, haloloweralkyl, aminosulfonyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, cycloalkoxy carbonyl, aminocarbonyl, diloweralkylaminocarbonyl or ##STR9## wherein n is 4 or 5. R.sub.3 is hydrogen, halogen, loweralkyl or phenyl or naphthyl, and
- R.sub.4 is hydrogen, acetyl, amino or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.