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US 4,226,772 AGranted
1-[(Dialkylamino)met hyl]-6-phenyl-4H-s-[4,3,-a][1,4]triazolobenzodiazepine N.sup.1 -oxide
AssigneeThe Upjohn Company
InventorJackson B. Hester, Jr.
Life of this patent
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Abstract
The compound of the formula ##STR1## wherein R' and R" are alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.1 is hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl or alkylthio in which the alkyl moiety is of 1 to 3 carbon atoms, inclusive; and wherein R.sub.2 is phenyl, o-chlorophenyl, o-fluorophenyl, or 2,6-difluorophenyl, is prepared by reacting a 1-halomethyl-6-phenyl-4H-s-triazo[4,3-a][1,4]-benzodiazepine with N,N-dimethylhydroxylamine and a strong base. The compound II and its pharmacologically acceptable acid addition salts have sedative and tranquilizing activity.
Claims5
A compound of the formula II:
- ##STR6## wherein R.sub.1 is hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl or alkylthio in which the alkyl moiety is of 1 to 3 carbon atoms, inclusive;
- and wherein R.sub.2 is phenyl, o-chlorophenyl, o-fluorophenyl, or 2,6-difluorophenyl or the pharmacologically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.