Back to results
US 4,226,766 AGranted
Novel method for preparing N(1)-alkylated-5-phenyl-7-substituted-2-deoxy-1,4-benzodiazepines
AssigneeCRC Compagnia di Recerca Chimica S.A.
InventorsFranjo Kajfez, Vitomir Sunjic, Vesna Caplar
Life of this patent
Estimating the term…
Abstract
A method for preparing N(1)-alkylated-5-phenyl-7-substituted deoxy-1,4-benzodiazepines utilizing a polyphosphoric acid alkyl ester of the formula: ##STR1## wherein R.sub.3 is an alkyl radical with up to 4 carbon atoms as the alkylating agent, is described.
Claims2
A process for preparing compounds of the formulas:
- ##STR17## which comprises reacting 0.5 mole of the methyl ester of polyphosphoric acid with 0.14 mole of the appropriate respective starting materials, to wit:
- a=2-amino-5-chloro(2'-hydroxyethylketimine)-benzophenone for 5 hours at about 160.degree. C.
- c=2-amino-5-chloro-(2'-hydroxy-2'-methylethylketimine)benzophenone for 8 hours at about 140.degree. C.
- e=2-amino-5-chloro-(1'-ethyl-2'-hydroxyethylketimine)benzophenone for 8 hours at about 140.degree. C.
- f=2-amino-5-chloro-(1'-ethyl-2'-hydroxyethylketimine)o-fluoro-benzophenone for 8 hours at about 140.degree. C., respectively, and isolating the respective products.
2 more elements
A process for preparing the compounds of the formulas:
- ##STR18## which comprises reacting the ethylester of polyphosphoric acid with the following respective starting materials:
- ##STR19## and isolating the respective products.
Dependencies are inferred from the claim text.