Immunological diagnostic reagents comprising thio-amine terminated latex particles
AssigneeHoffmann-La Roche Inc.
InventorGaetano Roncari
Life of this patent
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Abstract
A reagent for an immunological determination comprising water insoluble latex particles being formed from vinyl polymerizates and having free terminal functional groups of the formula: ##STR1## through which are bound an immunologically active material including materials for preparing this reagent and for utilizing this reagent for diagnostic purposes. The latex particles contain a core and an outer layer, said core being formed by polymerization of vinyl, or diene monomers or mixtures thereof with said polymerizates in said core carrying a functional group selected from group consisting of carboxyl, sulfonate or mixtures thereof and said outer layer being formed from vinyl polymerizates carrying said terminal functional group.
Claims20
A reagent for an immunological determination comprising a water insoluble reagent in the form of discrete latex particles, said reagent having a specific weight corresponding to about that of water, said latex particles being formed from vinyl polymerizates and having free terminal functional groups of the formula ##STR7## through which is bound an immunologically active material, wherein said latex particles contain a core and an outer layer, said core containing polymerizates formed from vinyl or dienes monomers or mixtures thereof, with said polymerizates in said core carrying a functional group selected from the group consisting of carboxyl, sulfonate or mixtures thereof and said outer layer containing vinyl polymerizates carrying said terminal funtional groups.
A process for preparing a reagent for immunological determination comprising reacting discrete latex particles formed from vinyl polymerizates and having a specific weight corresponding to about that of water and having free terminal functional group of the formula:
- ##STR8## with an immunologically active material, wherein said latex particles contain a core and an outer layer, said core formed by polymerization of vinyl, or diene monomers or mixtures thereof with said polymerizates in said core carrying a functional group selected from group consisting of carboxyl, sulfonate or mixtures thereof and said outer layer formed from vinyl polymerizates carrying said terminal functional group.
Dependencies are inferred from the claim text.