1-(2-Phenylureylene)imidazoles
AssigneeWestwood Pharmaceuticals, Inc.
InventorsPaul L. Warner, Jr., Edward J. Luber, Jr.
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Abstract
2(1-imidazolyl)phenylureylene compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic groups are intermediates for the preparation of 4-substituted amino imidazo[1,2-a]quinoxalines having immunosuppressant activity.
Claims12
A 1-(2-phenylureylene)imidazole of the formula:
- ##STR196## wherein:
- R.sup.2 is a radical bonded to the nitrogen by a carbon to nitrogen linkage and is selected from the group consisting of alkyl of from 1 to 17 carbon atoms, alkenyl having 16 carbon atoms, alkoxyalkyl in which the alkyl moiety has from 1 to 4 carbon atoms, halogenoalkyl in which the alkyl has from 1 to 2 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, cycloalkenyl having from 5 to 6 carbon atoms, 1-naphthyl, 2-naphthyl, phenoxymethyl, benzyl and styryl.
A compound according to clam 1 in which R.sup.2 is cycloalkyl having from 3 to 8 carbon atoms or cycloalkenyl having from 5 to 6 carbon atoms.
Dependencies are inferred from the claim text.