Purification of AT-125
AssigneeThe Upjohn Company
InventorDavid G. Martin
Life of this patent
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Abstract
Process for the purification of L-(.alpha.S,5S)-.alpha.-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125). Also provided are AT-125 analogs prepared in the process.
Claims4
A compound having the formula ##STR18## wherein R is selected from the group consisting of hydrogen and alkyl of from 1 to 8 carbon atoms, inclusive.
A process for preparing a compound having the formula ##STR19## which comprises (a) reacting a compound having the formula ##STR20## with a compound having the formula ##STR21## and (b) recovering the compound of formula II from the reaction mixture formed in (a) wherein R is selected from the group consisting of hydrogen and alkyl of from 1 to 8 carbon atoms, inclusive and X is halogen, with the proviso that when R is alkyl of from 1 to 8 carbon atoms, inclusive the product of (b) must be subjected to esterification.
Dependencies are inferred from the claim text.