Process for the manufacture of 2,6-dichloropyridine derivatives
AssigneeCassella Aktiengesellschaft
InventorsUlrich Buhler, Ernst Heinrich
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Abstract
The process for the manufacture of a compound of the formula ##STR1## comprising reacting in the presence of a basic nitrogen compound at elevated temperature phosphorus oxychloride with a compound of the formula ##STR2## in the molar ratio of phosphorus oxychloride to hydroxypyridine of 1:1 to 1.3:1 wherein R.sup.1 is hydrogen, alkyl having 1 to 8 carbon atoms, phenyl, carbalkoxy having 2 to 5 total carbon atoms, carbalkoxymethyl having 3 to 6 total carbon atoms or substituted phenyl having a substituent selected from the group consisting of chloro, bromo, methyl, ethyl, methoxy, ethoxy, cyano and nitro and R.sup.2 is hydrogen, cyano, nitro or acetyl.
Claims5
In the process for the manufacture of a compound of the formula ##STR10## comprising reacting in the presence of a basic nitrogen compound at elevated temperature phosphorus oxychloride with a hydroxypyridine of the formula ##STR11## wherein R.sup.1 is hydrogen, alkyl having 1 to 8 carbon atoms, phenyl, carbalkoxy having 2 to 5 total carbon atoms, carbalkoxymethyl having 3 to 6 total carbon atoms or substituted phenyl having a substituent selected from the group consisting of chloro, bromo, methyl, ethyl, methoxy, ethoxy, cyano and nitro and
- R.sup.2 is hydrogen, cyano, nitro or acetyl, the improvement comprises the molar ratio of phosphorus oxychloride to hydroxypyridine being 1:1 to 1.3:1.
Dependencies are inferred from the claim text.