Process for preparing p-chlorophenoxy-acetyl-piperonylpiperazine hydrochloride
AssigneeFarmaceutici Geymonat Sud S.p.A.
InventorsGian P. Gardini, Giancarlo Scapini, Armando Raimondi, Placido Poidomani
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Abstract
The subject compound, otherwise known as Fipexidum hydrochloride, is obtained by reacting the chloride of p-chlorophenoxyacetic acid with 1,4-bis-piperonylpiperazine, preferably in benzene solution under reflux conditions in the presence of a base such as sodium bicarbonate. The advantages of the process are low cost and high overall conversion due to easy recovery and recycle of relevant substances.
Claims7
A process for the synthesis of p-chlorophenoxyacetyl-piperonylpiperazine hydrochloride (I), which comprises reacting substantially pure 1,4-bis-piperonylpiperazine with the chloride of p-chlorophenoxyacetic acid.
A process for the synthesis of p-chlorophenoxyacetal-piperonylpiperazine hydrochloride (I), which comprises reacting substantially pure 1,4-bis-piperonylpiperazine with an equimolar amount or an excess of the chloride of p-chlorophenoxyacetic acid.
Dependencies are inferred from the claim text.