Beclomethasone dipropionate-hexane solvate and aerosols prepared therefrom
AssigneeSchering Corporation
InventorLawrence E. Finckenor
Life of this patent
Estimating the term…
Abstract
A beclomethasone dipropionate-hexane solvate, useful in the preparation of beclomethasone dipropionate aerosols is disclosed herein. The new n-hexane solvate is stable when stored as bulk, and convenient and cheap to prepare. The trichlorofluoromethane solvate prepared by contacting micronized n-hexane solvate with trichlorofluoromethane affords beclomethasone dipropionate-trichlorofluoromethane solvate which retains its small particle size.
Claims5
A solid composition of matter which consists of a beclomethasone dipropionate-n-hexane solvate characterized by an infrared absorption spectra substantially as shown in FIG. 1 and comprising 94-96% by weight beclomethasone dipropionate and 4-5% by weight n-hexane.
In a method for preparing a beclomethasone dipropionate-fluorotrichloromethane solvate in an aerosol formulation, the improvement which comprises contacting beclomethasone dipropionate-n-hexane solvate with trichlorofluoromethane in situ.
In a method for preparing an aerosol formulation of beclomethasone dipropionate in a suitable aerosol propellant suitable for inhalation therapy, the improvement which comprises utilizing beclomethasone dipropionate-n-hexane solvate.
Dependencies are inferred from the claim text.