Method for treating calcium imbalance and improving calcium absorption in mammals
AssigneeWisconsin Alumni Research Foundation
InventorHector F. DeLuca
Life of this patent
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Abstract
A method for treating or preventing metabolic bone disease characterized by loss of bone mass and of improving the calcium balance and calcium absorption of mammals, particularly of women in the post menopausal state, by administering at least one compound having the formulae ##STR1## where R.sub.1, R.sub.2 and R.sub.4 are each selected from the group consisting of hydrogen, hydroxyl, lower alkyl, acyl and O-alkyl and R.sub.3 is selected from the group consisting of hydrogen, hydroxyl, keto, lower alkyl, acyl and O-alkyl.
Claims5
A method for increasing the calcium absorption and retention within the body of mammals displaying evidence of, or having a physiological tendency toward, loss of bone mass, which comprises administering internally to said mammals, in a therapeutically effective amount, at least one compound selected from the group consisting of 1.alpha.-hydroxycholecalciferol, 1.alpha.-hydroxyergocalciferol, 1,25-dihydroxycholecalciferol, 1,25-dihydroxyergocalciferol and 1,24,25-trihydroxycholecalciferol.
Dependencies are inferred from the claim text.