Growth promotion
AssigneeImperial Chemical Industries PLC
InventorsDavid H. Davies, Geoffrey L. F. Norris
Life of this patent
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Abstract
This invention relates to the use of aplasmomycin, boromycin and acylated and hydrogenated derivatives thereof for modifying rumen metabolism in domestic ruminant animals, by reducing the proportion of methane formed, and increasing the proportion of propionate at the expense of methane and/or acetate. This modification of rumen metabolism is believed to improve growth in ruminant animals. The disclosure also describes compositions which may be used in the claimed method, an improved process for the production of aplasmomycin, and novel analogs of aplasmomycin and boromycin together with processes for their manufacture.
Claims6
A method, for use in the husbandry of domesticated ruminant animals to improve their rate of growth or efficiency of their food conversion, which comprises orally administering to such animals an effective amount of a compound of the formula:
- ##STR5## wherein R.sup.1 and R.sup.2 are each a hydrogen atom or an acetyl radical,
- and either carbon atoms 3, 3' and 9' are all in the R-configuration, X is an ethylene or trans-vinylene radical and Y is a radical Y.sup.1 of the formula:
- ##STR6## in which X.sup.1 is bonded to the CH.sub.2 group and the ring carbon atom is bonded to the oxygen atom, and in which X.sup.1 is an ethylene or trans-vinylene radical, and Z.sup.+ is a sodium, potassium, lithium, caesium or ammonium ion, or an ion of the formula R.sup.3 R.sup.4 R.sup.5 R.sup.6 N.sup.+ in which each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is hydrogen or 1-6 C alkyl;
- or carbon atoms 3, 3.varies. and 9' are all in the S-configuration, X is an ethylene radical and Y is a radical Y.sup.2 of the formula:
- ##STR7## in which the CH.sub.2 is bonded to the CH.sub.2 group shown in formula I, and the CH group is bonded to the oxygen atom, and in which X.sup.2 is an ethylene or cis-vinylene radical;
- or carbon atoms 3,3' and 9' are all in the S-configuration, X is an ethylene radical and Y is a radical Y.sup.3 of the formula:
- ##STR8## wherein X.sup.2 and Z.sup.+ have the meanings stated above.
Dependencies are inferred from the claim text.